Parameters TLC-Densitometric method Reported Method [ 26 ]
EZ SIM EZ SIM
Zocozet®a
((B.N.
1031118)
98.29%±
2.856  
101.25%±
1.553
101.1%±
1.341
100.86%±
1.470
F-test
(6.388)b
4.534 1.115    
Student's
t-test
(2.306)b
1.279 0.603    
Lipitrin®a
(B.N.
90478A)
101.78±
1.281
100.59±
1.967  
102.68±
0.858
102.74
0.960
F-test (6.388)b 2.227 4.193    
Student's
t-test
(2.306)b
1.304 2.193    
Alkorplus®a
(B.N.
008)
100.6±
1.516
102.46±
2.123
102.08±
0.725
101.82±
1.273
F-test
(6.388)b
4.364 2.778    
Student's
t-test
(2.306)b
1.968 0.583    
aAverage of 5 determinations
bThe values in the parenthesis are corresponding theoretical value at
p= 0.05 [degree of freedom in dosage form =8].
[26] Spectrophotometric determination of EZ and SIM using 1DD at 299.5 and 242.5 nm for EZ and AT, respectively and methanol asa solvent.
Table 3: Results of analysis of EZ and SIM in different dosage forms by proposed method and results of statistical comparison with the reported one.