Chromatographic condition
Resolution of
4-aminophenol and Paracetamol
Resolution of Ibuprofen and Ibuprofen impurity B
Flow mL/Minutes
0.9
7.7
1.6
1.0
7.9
1.7
1.1
7.6
1.6
Column temperature(°C)
22
7.7
1.6
25
7.9
1.7
28
7.6
1.6
Mobile phase variation (%)
90
6.3
2.0
100
7.9
1.7
110
6.2
1.9
Table 8:
Robustness.
