Method Pazufloxacin mesylate Cefoperazone sodium Sulbactam sodium Concentration Recovery % CV% Concentration Recovery % CV% Concentration Recovery % CV% RP-HPLC 0.5(µg/ml) 89.000 5.393 1 87.400 7.094 1 89.500 8.268 1.5 91.667 3.782 3 88.600 3.837 3 90.400 4.462 10 90.620 4.359 10 90.250 5.008 10 91.230 5.601 15 91.627 5.195 25 91.380 4.469 20 90.840 6.066 TLC 1(µg/ml) 88.500 5.876 6 91.583 6.588 4 88.525 7.117 3 88.600 3.311 18 90.844 4.373 12 92.100 6.198 12 92.933 2.260 20 89.420 5.715 16 93.256 6.173 18 92.194 3.929 23 92.396 5.887 19 90.868 7.095 a-CV%: Coefficient of Variation %

Table 2: Results of recovery of pazufloxacin mesylate, cefoperazone and sulbactam sodium in human plasma.