Spiked concentration
(ng/400 μL)
Observed concentration
(mean* ± S.D.
a
)
Coefficient of variation (%)
Accuracy (%)
Inter-day Dofetilide (n=5)
10
10.20 ± 0.14
10.30
102
25
23.36 ± 0.47
2.01
93.4
100
98.27 ± 5.14
5.23
98.3
Inter-day Amlodipine (n=5)
25
21.16 ± 2.17
10.26
84.65
100
101.87 ± 9.06
8.89
101.87
500
536.25 ± 50.44
9.41
107.25
a
Standard deviation
*Linear regression equations used: y=0.0060x for dofetilide and y=0.0017x for amlodipine
Table 3:
Inter-day precision and accuracy for determination of dofetilide and amlodipine in human plasma by the HPLC method.
