Quantitative determination

Preparation	Claimed		%Recovery^a ± SD		Standard addition technique
Seroquel^®tabletslabeled to contain 25.0mg QTF	HPTLC μg spot^-1	HPLC μg ml^-1	HPTLC	HPLC	HPTLC		HPLC
					Pure added μg spot^-1	%Recovery^b	Pure added μg ml^-1	%Recovery^b
	5.0	10.0	99.16 ± 1.27	100.67 ± 0.16	1.0	100.43	5.0	100.21
					1.5	99.52	10.0	100.35
					2.0	100.82	15.0	100.63
					Mean	100.27	Mean	100.39
					± SD	0.68	± SD	0.21

^a Average of five determinations.

^b Average of three determinations.

Table 5: Quantitative determination of QTF in the pharmaceutical preparation and application of standard addition technique, using the proposed chromatographic methods.