| Items |
HPTLC- densitometry |
HPLC |
HPLCmethoda |
| Mean |
99.16 |
100.67 |
99.21 |
| RSD |
1.17 |
0.16 |
0.97 |
| variance |
1.36 |
0.025 |
0.94 |
| n |
5 |
5 |
5 |
| Student’s t-test (2.44) |
2.36 |
1.05 |
- |
| F-test (6.338) |
2.45 |
1.18 |
- |
|
| The values between parenthesis are the theoretical values of t- and F-at P=0.05. |
| a HPLC method supplied by Astra Zeneca Company through personal communication using, the stationary phase; C18 column and mobile phase; methanol: acetonitrile:
0.02M dibasic ammonium phosphate (54:7:39, v/v/v) , UV detection at 254 nm and retention time 6mins. |
| Table 6: Statistical comparison between the results obtained, by applying the proposed methods and the manufacturer method for determination of QTF in
pharmaceutical preparation. |
