Method efficiency of bosentan across all

Method efficiency (%)
Ion Source	Extraction method	QC samples
Ion Source	Extraction method	LQC	MQC	HQC
ESI	Solid Phase Extraction	80.9	82.2	79.4
	Liquid Liquid Extraction	66.8	56.8	63.0
	Protein Precipitation	15.2	10.2	28.0
APCI	Solid Phase Extraction	84.4	88.7	83.2
	Liquid Liquid Extraction	65.9	54.1	62.7
	Protein Precipitation	14.4	10.6	13.8

Table 6: Method efficiency of bosentan across all QC levels after extraction with different techniques and analyzed on different ion source in MS (n=6).