dThdPase activitya) Immunohistochemistryb) Histopathological   Case Tumor Normal Epithelial Stromal diagnosisc) Organ No. tissue tissue cells cells   Uterine cervix 1 7.0 7.5 - + EC Ad Ca, HD   2 172.5 NOSd) - ++ EC Ad Ca, PUD   3 180.0 6.7 ++ + Sq Ca   4 236.0 11.0 ± ++ Sq Ca   5 241.0 14.2 ++ ++ Sq Ca   6 243.0 7.1 ++ - Sq Ca   7 260.6 168.2 ++ + Sq Ca   8 341.5 1.8 ++ + Sq Ca   9 343.0 31.0 + + Sq Ca   10 344.5 9.4 + + Sq Ca   11 410.5 17.7 + ± EC Ad Ca, PUD   12 572.3 26.6 ++ ++ Sq Ca   13 602.5 13.4 ++ ++ Sq Ca Endometrium 1 15.1 43.9 - + EM Ad Ca   2 20.6 28.0 - - EM Ad Ca   3 41.5 6.2 - + EM Ad Ca   4 50.8 8.4 + ++ EM Ad Ca   5 56.8 7.5 ± ± EM Ad Ca   6 70.0 1.3 - + EM Ad Ca   7 81.6 11.1 - + EM Ad Ca   8 81.8 8.3 - ++ Serous Ca   9 111.2 73.2 + ++ EM Ad Ca   10 117.6 9.2 + ++ EM Ad Ca   11 120.0 NOS + + EM Ad Ca   12 129.0 6.5 + ++ EM Ad Ca   13 135.0 5.1 - ++ EM Ad Ca   14 161.4 8.3 + ++ EM Ad Ca   15 187.0 24.4 + ++ EM Ad Ca   16 192.5 59.5 + + EM Ad Ca   17 200.0 10.6 ++ ++ EM Ad Ca   18 203.0 18.7 + + EM Ad Ca   19 229.0 28.6 + ++ Clear cell Ca   20 339.0 12.4 + ++ Serous Ca Ovary 1 11.5 NOS - + Mucinous Ca   2 12.3 NOS - + Endomet Ca   3 21.3 NOS + + Clear cell Ca   4 42.5 11.6 + - Mucinous Ca   5 48.0 NOS - ++ Serous cyst Ca   6 61.7 0.0 + ++ Mixed epithel Ca   7 73.0 NOS + + Clear cell Ca   8 75.0 NOS ++ + Clear cell Ca   9 101.0 14.8 + - Clear cell Ca   10 143.0 NOS NOS NOS Serous cyst Ca   11 238.4 NOS - ++ Serous cyst Ca   12 12852.5 19.3 ++ ++ Serous cyst Ca a) dThdPase activity is expressed as μg FU produced per mg protein per hour. b) Immunohistochemistry is scored by the number of cells showing positive staining for anti-dThdPase mAb: (-), negative staining; (±), weak and less than 10% positive cells; (+), 10% to 50% positive cells; (++), more than 50% positive cells. c) EC Ad Ca, endocervical adenocarcinoma; HD, highly differentiated; EMOD, endometrioid carcinoma; PUD, poorly differentiated adenocarcinoma; Sq Ca, squamous cell carcinoma; EM Ad Ca, endometrial adenocarcinoma; Serous Ca, serous adenocarcinoma; Serous cyst Ca, serous cyst adenocarcinoma; Endomet Ca, endometrial adenocarcinoma; Clear cell Ca, clear cell carcinoma; Mucinous Ca, mucinous cyst adenocarcinoma; Mixed epithel Ca; mixed epithelial adenocarcinoma. d) NOS, no specimen

Table 1: Activity of a pyrimidine nucleoside phosphorylase, dThdPase, immunohistochemistry in gynecological tumors and adjacent normal tissue.