Figure 5: Light photomicrography of liver of a rat after eight weeks of exposure to CdCl2. The trabecular structure of the liver is blurred. The hepatocyte cytoplasm is light, foamy and filled with vacuoles (V); cell sizes are enlarged, nuclear chromatin is more condensed (Cd). Necrosis of single hepatocytes and the nuclei are contracted, pycnotic with condensed chromatin (D arrow), cytoplasm is strongly acidophilic. Accumulation of mononuclear cells in the vicinity of sinusoids (S). The sinusoid walls show numerous Kupffer cells (Kc). H&E, x400