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Figure 1: Spinal cord injury through clipping induces necrosis and CD95 expression. In A, white matter of the thoracic spinal cord of injured rat 3 days after lesion. Coagulation and/or liquefaction necrosis evident in the lesioned thoracic segment, with cytoarchitectonic disorganization, axonal swelling, neuronal loss, vacuolization, hemorrhage, and pyknotic nuclei. In B and C, CD95 staining in white matter (control group after clipping). In D, CD95 staining in white matter of animal from the mannitol group. |