| Doses/Periods |
6 months |
12 months |
18 months |
| 0 mg/Kgbw |
-Normalstructure of seminiferous tubules which surrounded by vascularized densefibrous connective tissue, Tunica albuginea. Each seminiferous tubuleappeared normal with orderly arrangement of germ cells at different stages ofspermatogenesis
|
| 100mg/Kg bw |
-Normal structure with
regularspermatogenesis
|
-Fewalteration of seminiferous tubules |
-Somedamaged seminiferous tubules
-Presenceof necrosis zones |
| 200 mg/Kgbw |
-Perturbationof
spermatogenesis
-Fewzones of
degenerations
|
-Intenseperturbation of
spermatogenesis
-IntenseNecrosis
-Absenceof spz
-Degenerationof Epithelium
seminal |
-Intensearea of necrosis
-Perturbationof spermatogenesis
-Disorganizedspz with flagella on whirlpool form |
| 400 mg/Kgbw |
-Severalperturbation of spermatogenesis (only
presence of spz)
-IntenseNecrosis
-Alterationof adhesive junctions |
-Importantdegeneration of
seminiferoustubules
-SeveralNecrosis
-Degradationof epithelium
seminal (presence of few
spermatogonies)
- Intacts somaticcells |
-Morearea of necrosis zone
-Abnormaldisposition of spz flagella
-Presenceof abnormal cells |
