| Univariate Cox regression analysis |
| Parameter |
PFS |
OS |
| HR |
95% CI |
p-value |
HR |
95% CI |
p-value |
| Sex (female) |
1.611 |
0.837-3.099 |
0.153 |
1.823 |
0.962-3.458 |
0.066 |
| Age (>65) |
1.019 |
0.540-1.924 |
0.953 |
1.742 |
0.925-3.282 |
0.086 |
| PS (1) |
1.006 |
0.484-2.092 |
0.987 |
1.240 |
0.637-2.414 |
0.527 |
| CA19-9 (>37.5) |
1.289 |
0.621-2.567 |
0.451 |
1.287 |
0.599-2.532 |
0.351 |
| CEA (>5) |
1.311 |
0.654-2.444 |
0.397 |
1.214 |
0.673-2.479 |
0.359 |
| Status of primary tumor (resected) |
0.582 |
0.286-1.184 |
0.135 |
0.537 |
0.266-1.086 |
0.084 |
| Metastasis site |
|
|
|
|
|
|
| Liver |
1.129 |
0.496-2.570 |
0.773 |
0.852 |
0.394-1.843 |
0.685 |
| Lung |
0.741 |
0.364-1.413 |
0.343 |
0.752 |
0.351-1.484 |
0.363 |
| Bone |
1.033 |
0.432-2.470 |
0.941 |
1.173 |
0.489-2.815 |
0.721 |
| Peritoneum |
0.730 |
0.333-1.602 |
0.433 |
1.061 |
0.491-2.294 |
0.880 |
| Lymph node |
1.016 |
0.526-1.962 |
0.963 |
1.126 |
0.585-2.167 |
0.722 |
| Local recurrence |
0.278 |
0.066-1.171 |
0.081 |
0.512 |
0.157-1.671 |
0.268 |
| CD133 positive |
0.682 |
0.355-1.309 |
0.250 |
0.391 |
0.203-0.756 |
0.005 |
| Multivariate Cox regression analysis |
| Parameter |
PFS |
OS |
| HR |
95% CI |
p-value |
HR |
95% CI |
p-value |
| Sex (female) |
1.839 |
0.889-3.806 |
0.101 |
1.941 |
0.953-3.551 |
0.051 |
| Age (>65) |
1.581 |
0.763-3.277 |
0.218 |
2.842 |
1.273-6.342 |
0.011 |
| Status of primary tumor (resected) |
0.567 |
0.266-1.209 |
0.142 |
0.309 |
0.137-0.698 |
0.005 |
| Local recurrence |
0.314 |
0.066-1.488 |
0.144 |
0.641 |
0.162-2.537 |
0.526 |
| CD133 positive |
0.759 |
0.387-1.490 |
0.423 |
0.339 |
0.162-0.711 |
0.004 |
PFS: Progression-Free Survival; OS: Overall Survival; HR: Hazard Ratio; PS: Performance Status; Mg: Magnesium. |
