| Univariate Cox regression analysis |
| Parameter |
PFS |
OS |
| HR |
95% CI |
p-value |
HR |
95% CI |
p-value |
| Sex (female) |
1.504 |
0.807-2.802 |
0.198 |
1.396 |
0.758-2.571 |
0.285 |
| Age (>65) |
1.317 |
0.693-2.502 |
0.401 |
1.813 |
0.950-3.460 |
0.071 |
| PS (1) |
1.500 |
0.763-2.948 |
0.240 |
1.41 |
0.714-2.787 |
0.322 |
| CA19-9 (>37.5) |
1.388 |
0.712-2.403 |
0.399 |
1.382 |
0.746-2.478 |
0.389 |
| CEA (>5) |
1.369 |
0.698-2.488 |
0.411 |
1.397 |
0.765-2.494 |
0.412 |
| Status of primary tumor (resected) |
0.972 |
0.487-1.938 |
0.935 |
0.742 |
0.373-1.479 |
0.397 |
| Metastasis site |
|
|
|
|
|
|
| Liver |
0.542 |
0.246-1.198 |
0.130 |
0.593 |
0.271-1.297 |
0.191 |
| Lung |
0.585 |
0.288-1.187 |
0.137 |
0.74 |
0.384-1.426 |
0.369 |
| Bone |
1.549 |
0.640-3.752 |
0.332 |
1.776 |
0.720-4.381 |
0.212 |
| Peritoneum |
2.019 |
0.907-4.495 |
0.085 |
2.879 |
1.266-6.549 |
0.012 |
| Lymph node |
1.601 |
0.801-3.202 |
0.183 |
1.629 |
0.844-3.147 |
0.146 |
| Local recurrence |
0.832 |
0.255-2.720 |
0.761 |
0.996 |
0.306-3.249 |
0.995 |
| CD133 positive |
0.500 |
0.249-1.003 |
0.051 |
0.405 |
0.205-0.798 |
0.009 |
| Multivariate Cox regression analysis |
| Parameter |
PFS |
OS |
| HR |
95% CI |
p-value |
HR |
95% CI |
p-value |
| Sex (female) |
1.456 |
0.712-2.977 |
0.303 |
1.457 |
0.721-2.467 |
0.152 |
| Age (>65) |
2.666 |
1.063-6.684 |
0.037 |
2.442 |
1.082-5.510 |
0.032 |
| PS (1) |
1.693 |
0.814-3.521 |
0.159 |
|
|
|
| Liver |
0.732 |
0.270-1.986 |
0.541 |
1.251 |
0.511-3.067 |
0.624 |
| Lung |
0.867 |
0.374-2.008 |
0.739 |
|
|
|
| Bone |
|
|
|
1.008 |
0.371-2.735 |
0.988 |
| Peritoneum |
1.958 |
0.768-4.993 |
0.160 |
1.772 |
0.669-4.695 |
0.250 |
| Lymph node |
1.194 |
0.546-2.610 |
0.657 |
0.755 |
0.355-1.606 |
0.466 |
| CD133 positive |
0.559 |
0.259-1.209 |
0.140 |
0.316 |
0.146-0.686 |
0.004 |
|
