Follow-up diagnosis of malignancy? Initial cytologic interpretation Details of follow-up, laterality of effusion to transplanted lung
No (57) Negative for malignancy (54) 52 Ipsilateral 1 Contralateral
Atypical favor reactive (1) Ipsilateral
Atypical lymphocytes (3) Ipsilateral, flow cytometry negative
Yes (6) Negative for malignancy (5) 2 patients (1 fluid each) with lung biopsy demonstrating PTLD - both ipsilateral 1 patient (1 fluid) with CLL/SLL involvement of pleural space by flow cytometry - ipsilateral 1 patient (2 fluids) with pleural biopsy demonstrating adenocarcinoma (3rd effusion called atypical, suspicious, see below) - both contralateral
Atypical suspicious for malignancy (1) Patient found to have pleural involvement by poorly differentiated adenocarcinoma favored to be metastasis - contralateral
Table 2: Correlation of follow-up with initial cytologic interpretation (n=number of effusions with this diagnosis).