Patient follow-up
Cytologic features No malignancy (n=32) Epithelial malignancy (n=1) Hematolymphoid malignancy (n=3) P value
Location of effusion       0.06^
Contralateral 1 (3%) 1 (100%) 0 (0%)
Ipsilateral 31 (97%) 0 (0%) 3 (100%)
Prominent nucleoli 15 (47%) 1 (100%) 0 (0%) 0.29*
Cell clusters 11 (34%) 1 (100%) 1 (33%) 0.17*
Cell clusters with community borders 1 (3%) 1 (100%) 0 (0%) 0.01*
Vacuolated cells 15 (47%) 1 (100%) 0 (0%) 0.29*
Recurrent effusion 8 (25%) 1 (100%) 1 (33%) 0.29
* These p values were calculated excluding hematolymphoid malignancies as these are features of epithelial malignancies ^ This p value was calculated for patients with a unilateral lung transplant (n=9) and only for epithelial malignancies (p=0.06), as all hematopoietic malignancies developed in patients with bilateral lung transplants.
Table 3: Correlation of follow-up malignancy with cytologic and clinical features of effusion samples (n=number of patients).