Factors Category p53 expression Pvalue
    Negative (n=166) 1+ (n=62) Overexpression (n=35)  
Age (years) Mean±SD
(range)
58.5±14.0
(25~87)
54.4 ± 13.1 (26~81) 58.3±12.8
(32~84)
0.135
Nuclear grade 1,2 157 58 21  
  3 4 2 13 (38%) <0.0001
ER - 11 5 21 (60%)  
  + 155 57 14 <0.0001
PgR - 19 10 26 (74%)  
  + 147 52 9 <0.0001
HER2 - 149 49 13  
  + 16 12 22 (63%) <0.0001
Ki-67 - 141 44 8  
  + 25 18 24 (69%) <0.0001
Surgery Bp 90 42 26 (74%)  
  Bt 74 19 9 (26%) 0.219
Adjuvant therapy None 113 41 26 (74%)  
Chemotherapy 0 1 5  
  Endocrine therapy 49 19 4  
  Chemo-endocrine therapy 3 0 0  
Subtype Luminal A-like 125 38 4 (11%)  
Luminal B-like 18 10 6(17%)  
HER2 3 3 18 (51%)  
Luminal/HER2 13 9 4 (11%)  
Triple Negative 7 2 3 (9%)  
Table 3a: p53 expression and clinicopathological factors in patients with DCIS.