| Parameters |
N |
NFκB
n(%) |
p |
HIF-1α
n(%) |
p |
P-selectin
n(%) |
P |
|
Total number |
67 |
48(71.6) |
|
49(73.1) |
|
18(23.9) |
|
Age
<68 years
≥68 years |
26
41 |
17 (65.4)
31 (75.6) |
0.41 |
18 (69.2)
31 (75.6) |
0.58 |
6 (23.1)
12 (26.3) |
0.78 |
Sex
Male
Female |
38
29 |
31(81.6)
17(58.6) |
0.056 |
27(71.0)
22(75.9) |
0.78 |
7(18.4)
11(37.9) |
0.17 |
Tumour site
Colon (R+L+T)
sigmoid
Rectum |
34
24
9 |
27(79.4)
17(70.8)
4(44.4) |
0.11 |
24(70.6)
20(83.3)
5(55.5) |
0.24 |
8(23.5)
8(33.3)
2(22.2) |
0.67 |
Tumour grade
Well D
Moderately D
Poorly D |
26
34
4 |
20(76.9)
23(67.6)
3(75.0) |
0.57 |
19(73.1)
27(79.4)
1(25.0) |
0.066 |
8(30.8)
8(23.5)
1(25.0) |
0.81 |
pTNM Stage
I
II
III+IV |
6
32
29 |
2(33.3)
25(78.1)
21(72.4) |
0.082 |
5(83.4)
25(78.1)
19(65.5) |
0.45 |
4(66.7)
10(31.2)
4(13.8) |
0.022 |
pT stage
T1+T2
T3
T4 |
7
45
15 |
2(28.6)
33(73.3)
13(86.7) |
0.017 |
5(71.4)
34(75.5)
10(66.7) |
0.79 |
4(57.1)
11(24.4)
3(20.0) |
0.24 |
pN stage
Node negative
Node positive |
38
29 |
27(71.0)
21(72.4) |
1.0 |
30(78.9)
19(65.5) |
0.27 |
14(36.8)
4(13.8) |
14(36.8)
4(13.8) |
| Expression was assessed by immunohistochemistry. Data are given as positive cases and percentage (in brackets) based on N. Association between markers and clinicopathological data was obtained using the Chi-square test or Fisher’s exact test. D: differentiated; in bold significant p values. |
