| |
n(% of 33 classified cusps with HO) |
| Histopathological features of HO |
|
| Focal and minute HO/multifocal HO |
9 (27.3%)/26 (72.7%) |
| Enchondral ossification-like features from cartilage |
9 (27.3%) |
| Histopathological features in the background of cusps with HO |
|
| Neovessels (ThKA-Vs and/or ThNC-Vs) |
32 (97.0%) |
| Metaplastic cartilage (hyaline and/or fibrous cartilage) |
17 (51.5%) |
| Histopathological features near/adjacent to HO |
|
| Neovessels (ThKA-Vs and/or ThNC-Vs) |
27 (81.8%) |
| No distinct neovascularized vessels |
6 (18.2%)* |
| Lymphoplasmacytic infiltration |
24 (72.7%)† |
| Metaplastic cartilage (hyaline and/or fibrous cartilage) |
10 (30.3%)‡ |
HO: heterotopic ossification; ThKA-Vs: thick, arteriole-like neovascularized vessels; ThNC-Vs: thin capillary-like neovascularized vessels.
*Including 1 non-neovascularized cusp and 5 cusps in which neovascularization was present in areas distant from HO.
†All were found in neovascularizedstroma.
‡Including 9 cusps with enchondral ossification-like features and 1 cusp with “vessel-independent heterotopic ossification” from cartilage. |
