Figure 2: Immunohistologic findings in the 2013 lymph node. Atypical follicle with large cells within follicles and in mantle zones (A); these cells are highlighted by stains for OCT2 (B), HGAL (inset B), and BCL2 (C); a rare atypical follicles with confluence of large cells (D) highlighted by OCT2 (E) and BCL2 (F); interfollicular areas are studded with atypical large B-cells highlighted by CD20 in a TCRLBCL-like areas (G); Ki67 highlights a low proliferation in grade 1-2 follicular lymphoma (H); confluent focus of atypical large cells show staining for CD20 (I), and an increased growth fraction (J), but lack CD30 (K) and CD15 (L), confirming the presence of a diffuse large B-cell lymphoma. |