Figure 1: (A) Schematic diagram of human Mdm2 and the location of cancer related mutations in Mdm2 according to COSMIC (Catalogue of Somatic Mutations in Cancer) database (http://www.sanger.ac.uk/genetics/CGP/ cosmic/). (B and C) Primary MEFs were transfected with various Mdm2 expression vectors or empty vector. Cell viability after exposure to 50 μM Etoposide for 24 hours (B) or exposure to 50 μM H2O2 for 24 hours (C) as measured by tripan blue stain .Error bar is indicate SE.