Voided urine n=5 Bladder washings n=12 p-value
  HPV (+) n=1 HPV (-) n=4 HPV (+) n=4 HPV (-) n=8
General features          
Background          
clean 0 2 ( 50% ) 1 ( 25% ) 4 ( 50% ) 0.338
Inflammation 0 0 1 ( 25% ) 0 0.294
Bloody 1 ( 100% ) 2 ( 50% ) 3 ( 75% ) 3 ( 37.5% ) 0.294
Tumor diathesis 1 ( 100% ) 0 1 ( 25% ) 1 ( 12.5% ) 0.191
Arrangement         1.000
Mostly clusters 0 2 ( 50% ) 2 ( 50% ) 4 ( 50% )  
Single cell and clusters 0 1 ( 25% ) 1 ( 25% ) 2 ( 25% )  
Mostly single cells 1 ( 100% ) 1 ( 25% ) 1 ( 25% ) 2 ( 25% )  
Cell uniformity         0.117
Monomorphic 0 3 ( 75% ) 2 ( 50% ) 7 ( 87.5% )  
Pleomorphic 1 ( 100% ) 1 ( 25% ) 2 ( 50% ) 1 ( 12.5% )  
Nuclear features          
Chromatin pattern         1.000
Fine granular 0 3 ( 75% ) 2 ( 50% ) 2 ( 25% )  
Granular 1 ( 100% ) 1 ( 25% ) 2 ( 50% ) 6 ( 75% )  
Conspicuous nucleoli         0.538
Absent 1 ( 100% ) 3 ( 75% ) 2 ( 50% ) 7 ( 87.5% )  
Indistinct/small 0 1 ( 25% ) 1 ( 25% ) 1 ( 12.5% )  
Present/occasional 0 0 1 ( 25% ) 0  
Cytoplasmic features          
Border         0.620
Indistinct 0 1 ( 25% ) 3 ( 75% ) 4 ( 50% )  
Distinct 1 ( 100% ) 3 ( 75% ) 1 ( 25% ) 4 ( 50% )  
Texture         0.319
Homogenous 1 ( 100% ) 2 ( 50% ) 0 6 ( 75% )  
Variable 0 2 ( 50% ) 4 ( 100% ) 2 ( 25% )  
Table 3: Comparison of cytopathological findings between HPV-positive UC and HPV-negative UC.