Parameters Group I Subgroup IIa Subgroup IIb Subgroup IIIa Subgroup IIIb Pt (N) 0.29 ± 0.02 0.09 ± 0.02* 0.17 ± 0.02*# 0.16 ± 0.02*# 0.30 ± 0.03#@$ PTT (N) 0.63 ± 0.07 0.27 ± 0.05* 0.44 ± 0.04*# 0.38 ± 0.04*# 0.53 ± .05*#@$ FR (sec) 5.16 ± 0.46 2.91 ± 0.59* 3.91± 0.66*# 4.25 ± 0.22*# 4.81 ± 0.22#@

*Significant compared to group I (P<0.05). #Significant compared to subgroup IIa (P<0.05). @Significant compared to subgroup IIb (P<0.05). $Significant compared to subgroup IIIa (P<0.05). Table 1: Mean ± SD Pt, PTT and FR time in group I, subgroups IIa, IIb, IIIa and IIIb.