Figure 6: (a): Section of mature Westar rats cerebrum of control group (I) showing normal, intact cerebral tissue. H&E 4X:10X. (b-d): Section of mature Westar rats cerebrum of exposed group to tartrazine (II) (b): showing slightly vacuolations in cerebral cortex (arrow), gray matter (G). (c): showing severe vacuolations in cerebral medulla (arrow), white matter (W). (d): higher magnification of Figure c showing the same. b-d) H&E b,c) 4X:10X. d) Obj. x20: 10X. (e): Section of mature Westar rats cerebrum of exposed group to tartrazine (II) showing the oligodendrocyte with small, round, relatively dark nuclei (arrow head) and, were often in close proximity to neurons and have no any histological changes in the cerebral gray matter. And also, some neurons have a large nuclei which appeared from deeply basophilc to pyknotic and acidophilic cytoplasm (arrow) H&E 4X0: 10X.