Figure 1: A case of moderately differentiated adenocarcinoma with C-pattern. (a) Schema of gastric cancer with C-pattern submucosal invasion. (b) Endoscopic ultrasonography shows diffuse submucosal invasion (white arrowhead). The border between the mucosal and submucosal layers appears obscure. (c) HE staining (×100). Cancer cells invade to the submucosal layer diffusely, and the muscularis mucosae is widely destroyed (black arrow-head).