Figure 5: Histology and immunohistochemistry of gastric cancer with P-pattern submucosal invasion. A case of moderately differentiated adenocarcinoma of type 0-IIc, measuring 8 mm in diameter, with submucosal invasion of >500 μm. The mucosal layer is I-type, while the submucosal layer is G-type. (a) HE staining (×100). (b) MUC5AC-positive only in the submucosal layer (black arrow-head) (×100). (c) MUC6-negative (×100). (d) MUC2- negative (×100). (e) CD10-positive only in the mucosal layer (black arrow-head) (×100). (f) MI Ki-67 is 70%.