Markers Cells n Mean SD Min Q1 Median Q3 Max p-value MMP2 Tumor 51 58.42 26.42 11.66 38.82 50.64 82.33 100.0 0.3245 Stromal 51 55.32 21.48 21.44 34.31 52.78 71.31 99.15 MMP9 Tumor 55 49.87 29.85 1.62 26.14 47.71 77.65 99.65 0.0295 Stromal 55 58.78 29.58 0.62 41.0 62.49 85.15 97.98 MMP14 Tumor 51 86.25 20.41 8.43 78.91 97.84 100.0 100.0 < 0.0001 Stromal 51 51.89 28.53 1.25 28.8 57.17 75.68 99.79 TIMP1 Tumor 53 83.75 14.81 42.49 77.1 84.29 96.98 100.0 0.0002 Stromal 53 72.31 20.3 19.77 56.64 71.67 88.46 100.0 TIMP2 Tumor 52 42.08 25.73 0.77 23.29 37.53 56.22 96.39 < 0.0001 Stromal 52 59.04 25.58 5.72 35.0 67.77 80.17 94.34

Comparisons between means were performed using the paired t-test

Table 1: Comparison of mean percentages of tumor and stromal cells immunopositive in CIN 3 (Group 1).