Markers Cells n Mean SD Min Q1 Median Q3 Max p-value MMP2 Tumor 30 63.81 30.13 4.9 38.5 75.46 90.48 99.36 0.5244 Stromal 30 67.8 26.15 6.9 51.54 77.86 88.3 98.2 MMP9 Tumor 26 52.28 32.32 1.73 15.87 54.03 84.57 94.29 0.0357 Stromal 26 65.94 24.13 9.77 43.35 74.17 85.23 93.56 MMP14 Tumor 27 89.13 17.48 35.79 84.17 100.0 100.0 100.0 < 0.0001 Stromal 27 56.46 24.95 11.39 40.29 56.93 81.46 92.67 TIMP1 Tumor 18 81.58 16.73 45.74 67.3 86.73 95.78 99.79 0.7674 Stromal 18 82.81 15.62 48.1 71.84 84.82 96.37 100.0 TIMP2 Tumor 19 51.11 23.96 5.19 27.27 60.97 68.59 79.48 0.0123 Stromal 19 63.91 22.04 18.39 42.73 64.24 79.18 96.46

Comparisons between means were performed using the paired t-test

Table 2: Comparison of mean percentages of tumor and stromal cells immunopositive in CIN 3 (Group 2).