Markers Cells n Mean SD Min Q1 Median Q3 Max p-value MMP2 Tumor 30 64.85 26.87 12.1 45.63 72.71 85.99 99.27 0.7785 Stromal 30 66.54 20.39 13.57 55.08 67.81 81.35 100.0 MMP9 Tumor 26 54.68 31.59 0.71 28.61 55.49 85.62 100.0 0.2659 Stromal 26 63.19 28.87 0.17 35.37 75.36 86.33 100.0 MMP14 Tumor 27 80.18 26.26 17.21 54.27 100.0 100.0 100.0 0.0224 Stromal 27 64.96 27.93 14.58 45.3 74.57 87.32 98.14 TIMP1 Tumor 18 82.3 15.12 54.07 74.85 88.41 93.32 99.51 0.9072 Stromal 18 82.76 16.03 33.94 76.74 86.15 94.26 98.96 TIMP2 Tumor 19 44.3 19.65 14.69 28.59 42.47 53.01 78.76 0.0174 Stromal 19 61.15 16.9 8.43 55.24 61.9 71.33 89.4

Comparisons between means were performed using the paired t-test

Table 3: Comparison of mean percentages of tumor and stromal cells immunopositive in Invasive Carcinoma (Group 2)