Markers Cells n Mean SD Min Q1 Median Q3 Max p-value MMP2 Tumor 37 76.05 20.14 28.58 64.81 82.99 91.39 99.96 0.1953 Stromal 37 69.99 18.87 6.51 62.21 72.99 84.9 97.81 MMP9 Tumor 46 42.01 38.56 0.07 3.45 35.74 81.42 100.0 0.0009 Stromal 46 53.2 35.51 0.07 17.89 66.23 85.74 95.41 MMP14 Tumor 35 85.75 25.15 3.39 83.23 100.0 100.0 100.0 < 0.0001 Stromal 35 66.06 23.79 10.9 45.64 69.83 87.49 100.0 TIMP1 Tumor 46 76.53 15.08 40.26 68.03 77.66 88.45 99.65 0.0076 Stromal 46 83.72 11.64 59.55 76.37 84.52 93.81 100.0 TIMP2 Tumor 38 37.69 24.58 0.0 17.42 37.44 49.46 88.57 < 0.0001 Stromal 38 65.11 21.73 3.13 49.08 64.21 86.38 100.0

Comparisons between means were performed using the paired t-test

Table 4: Comparison of mean percentages of tumor and stromal cells immunopositive in Invasive Carcinoma (Group 3)