| Parameters |
Group I
(Control) |
Group II
(10 ppm) |
Group III
(30 ppm) |
Group IV
(50 ppm) |
| Hematological Parameters |
|
|
|
|
| RBC count (million/cu mm) |
7.81 ± 0.14 |
6.95 ± 0.21* |
6.89 ± 0.31* |
6.67 ± 0.21* |
| Hb level (g/dl) |
15.4 ± 0.16 |
14.37 ± 0.24* |
14.25 ± 0.21*** |
13.68± 0.21*** |
| WBC Count (1000/cu mm) |
4400 ± 136.63 |
4183.33 ± 192.21NS |
3320 ± 88.69*** |
1920 ± 173.97*** |
| Liver Function |
|
|
|
|
| ALT (I/U) |
42.17 ± 3.97 |
45.2 ± 3.47NS |
55 ± 4.89NS |
99.60 ± 2.34*** |
| AST (I/U) |
139.5 ± 9.42 |
159 ± 4.17NS |
159 ± 4.17NS |
199.80 ± 11.62*** |
| ALP (I/U) |
65.4 ± 6.33 |
114.20 ± 6.76*** |
143.40 ± 6.68*** |
151.40 ± 9.99*** |
| Histological Injury Score |
|
|
|
|
| Liver Injury Score |
8.17±0.40 |
13.33±0.76*** |
14.67±0.42*** |
18.33±0.21*** |
| Kidney Injury Score |
1±0 |
2.67± 0.21*** |
2.67±0.21*** |
3±0.26*** |
| Spleen Injury Score |
1±0 |
5±0.26*** |
5.67±0.21*** |
5.67±0.21*** |
| Heart Injury Score |
1±0 |
2.50±0.21*** |
3.67±0.22*** |
5.0±0.37*** |
| Accumulated Arsenic in Organs |
|
|
|
|
| Liver |
0.48±0.05 |
45.23±1.37*** |
41.89±0.89*** |
38.56±0.88* |
| Kidney |
0.42±0.05 |
11.48±1.12*** |
8.61 ± 1.10*** |
5.44± 0.59* |
| Spleen |
0.50± 0.04 |
19.98±0.87*** |
17.82±0.76*** |
15.57 ±0.68* |
| Heart |
0.43± 0.01 |
5.15±0.03*** |
4.12±0.02*** |
2.01±0.01* |
|
| NS denotes not significant; *Values are significant at (p<0.05); *** Values are significant at Highly significant (p<0.001)obtained from ANOVA test followed by Duncan’s multiple range test (DMART). |
| Table 1:Effect of arsenic on hematological parameters, liver function test, histological injury score and arsenic accumulation pattern in Wistar Albino rats during sub-chronic (90 days) treatment of sodium arsenite. |
