Experimental domain
Factor —α — 1 0 1 α
Extraction temperature (T, °C) 13.07 25.00 42.50 60.00 71.93
Equilibrium time (teq, min) 3.18 10.00 20.00 30.00 36.82
Extraction time (tex, min) 1.59 5.00 10.00 15.00 18.41
Table 1: Factor levels and experimental domain applied to optimize the HS-SPME experimental conditions.