Model term

Coefficient estimation

Standard error

F-value

Prob>F

Intercept

5.230

0.120

-

-

Pressure (X1)

1.100

0.084

168.510

<0.0001

Temperature (X2)

-0.190

0.084

5.130

0.0580

Co-solvent flow rate (X3) X1:X2
X1:X3
X2: X3
X12
X22
X32

0.520
0.007
0.170
0.006
0.051
-0.400
-0.380

0.084
0.120
0.120
0.120
0.120
0.120
0.120

37.930
0.004
2.040
0.003
0.190
11.630
10.570

0.0005
0.9500
0.1966
0.9565
0.6770
0.0113
0.0140

R2=0.9713; Adj R2 = 0.9344, SD=0.24; CV=4.88%
X1, X2 and X3 are the main effects; X1X2 , X1X3 and X2 X3 are the interaction effects
Table 4: Regression coefficient analysis of response function to predict extraction yield of S.crispus.