Sample (Reference) Retention Time Precursor Reaction Ions Ion 1 Ion 2 Amphetamine 8.75 136.1 119 NA Methamphetamine 10.07 150.2 119 91.2 MDMA 11.39 194.1 163 NA Heroin 13.73 370.4 328.2 268.3 Cocaine 13.74 304.1 182.1 150.3 Benzoylecognine 14.3 290.2 272.1 168.1 Flurazepam 15.75 388.1 315.3 288.3 Alprazolam 19.08 309.3 281.2 274.3 Lorezepam 19.09 321.2 275.5 302.9 Diazepam 20.85 285.3 257.2 228.2 THC-OH 27.51 331.2 313.1 NA THC-OH-d3 27.45 334.2 316.2 NA

Table 3: The retention times of all the compounds, Note: The information was obtained by running the standard mix of the compounds and tuning the compounds in the LC-MS instrument. NA represents that there was only 1 reaction ion for the compound.