Figure 2: β-receptor signaling regulates rAAV transduction in vivo. (A) rAAVCMV- hGH vector was directly injected into the heart muscle of adult FVB mice, and then ISO was administered into the peritoneum 5 min later. Blood was obtained every two weeks, and the concentration of human growth hormone (hGH) in serum was measured by ELISA. Data are mean±SEM, *p<0.05, **p<0.01 (n=6) vs PBS control. (B) β-adrenergic receptor down regulation by chronic stimulation of ISO using an osmotic pump. rAAV-CMV-hGH vector was directly injected into the hearts of adult FVB mice 4 days after the pump was inserted. Data are mean±SEM, *p<0.01 (n=6) vs. PBS control.