Figure 2: Structure of HDAd expressing low-density lipoprotein receptor (LDLR). A. HDAd vector containing LDLR cDNA on pΔ28 or pΔ21 backbone. HDAd-P-LDLR has the pΔ28 backbone and HDAd-AI-LDLR and HDAd-AI-LDLR-E4 have the pΔ21 backbone. AdE4, Ad E4 promoter. Other abbreviations are as described in Figure 1 legend. B. HDAd containing human LDLR gene. The intron 1 of LDLR gene was removed and replaced with cDNA.