Site of Action Gene Promoter Region Anomaly
Serotonin transporter SLC6A4 5-HTTPLR SSRI-efficacy
P-Glycoprotein ABCB1 Upstream/downstream promoters ABC-transporter1
CRH-receptor of HPA axis2 CRHR1 Luciferase reporter plasmid Suicidality
5-HT2A receptor HTR2A -1438G/A (rs6311) Overdensity
Glucocorticoid receptor NR3C1 Luciferase reporter plasmid Stress adaptation
BDNF3 neurotrophin BDNF Multiple promoters AD-enhanced plasticity
AD-drug action MAGI2, DTWD1. WDFY4, and CHL1 Multiple promoters Symptom-exacerbation
1Transportation of a wide variety of substrates across extra- and intracellular membranes
2Corticotrophin-releasing hormone (CRH) of the hypothalamic-pituitary-adrenal axis (HPA)
3Brain derived neurotrophic factor (BDNF)
Table 1: The pharmacogenetics of certain genes associated with the pathophysiology or efficacy, metabolism, or availability of pharmacotherapeutic agents in mood disorders.