Site of Action |
Gene |
Promoter Region |
Anomaly |
|
|
|
|
Serotonin transporter |
SLC6A4 |
5-HTTPLR |
SSRI-efficacy |
|
|
|
|
P-Glycoprotein |
ABCB1 |
Upstream/downstream promoters |
ABC-transporter1 |
|
|
|
|
CRH-receptor of HPA axis2 |
CRHR1 |
Luciferase reporter plasmid |
Suicidality |
|
|
|
|
5-HT2A receptor |
HTR2A |
-1438G/A (rs6311) |
Overdensity |
|
|
|
|
Glucocorticoid receptor |
NR3C1 |
Luciferase reporter plasmid |
Stress adaptation |
|
|
|
|
BDNF3 neurotrophin |
BDNF |
Multiple promoters |
AD-enhanced plasticity |
|
|
|
|
AD-drug action |
MAGI2, DTWD1. WDFY4, and CHL1 |
Multiple promoters |
Symptom-exacerbation |
1Transportation of a wide variety of substrates across extra- and intracellular membranes
2Corticotrophin-releasing hormone (CRH) of the hypothalamic-pituitary-adrenal axis (HPA)
3Brain derived neurotrophic factor (BDNF) |