 Tract: Tissue specific regulation by the Hoxa family homeobox transcription
factors are important in the development in the oviducts (Hoxa9), uterus
(Hoxa10 and Hoxa11), cervix (Hoxa11 and Hoxa13) and vagina (Hoxa11 and
Hoxa13) as shown. Wnt family genes are believed to be involved in the anteriorposterior
as well as radial patterning. Specifically shown here is Wnt7a, which
is required for maintenance of Hoxa10 and Hoxa11 expression in the uterus.
Also illustrated is the gradient of BMP4 expression, strongest in the vagina and
weakest in the uterus. The opposite gradient has been noted for Wnt7a |
