|Figure 2: Aortic structure with hPRDX6-gene delivery shows less HCD-induced
remodeling. High resolution ultrasound (HRUS) was used to measure various
A. shows quantification of blood flow velocities in the luminal center of the abdominal region of the aorta in 3-5 animals in the indicated treatment after 20 weeks on HCD. Representative capture images from the analysis are shown just above. Note that the AAV/hPRDX6-HCD animals have significantly lower systolic blood velocity than the AAV/Neo-HCD animals.
B. shows quantification of the cross-sectional area of the thoracic region of the aorta in 3-5 animals from each animal group by HRUS with representative captured images from the analysis. Note that the AAV/hPRDX6-HCD animals have a significantly larger cross sectional area than the AAV/Neo-HCD animals, indicating significant efficacy.
C. shows quantification of the wall thickness of thoracic region of the aorta. Note that the AAV/hPRDX6-HCD animals have a thinner wall thickness than the AAV/Neo-HCD animals.