Figure 8: Immunohistochemical studies of GCDFP-15/PIP in sections derived from SS biopsies and healthy volunteer. In healthy volunteer the staining is more concentrated towards the apical pole of mucuse cells (acinous marked with m in figure 8A’) and ductal cell are negative, is also possible observe some immunorective material in the lumen of mayor ducts (asterisk in figure 8A). In SS patients the immunoreactivity for GCDFP-15/PIP is faint in mucus acini (see m in figure 8B’), no major changes were observed in serous acinar cells but slightly increase in the intensity of the immunoreactivity in this cells.