Figure 3: In the murine model of angiogenesis aortas from older mice show a reduced angiogenic response. (A) Male mice (aged as indicated) were embedded in Collagen I and supplemented with 1% FBS and 30 ng/ml VEGF. Mean sprout formation was calculated from at least 10 rings each point represents the mean value from one animal. Error bars represent the standard error of the mean and significance was calculated using individual student T tests compared to the 6 week value.