Figure 2: Interphase functions of cohesin. In addition to maintaining sister chromatid cohesion in trans (A) cohesin also mediates cis interactions between distal
enhancers and promoter regions in association with activators and transcription factors (B). Additionally, cohesin is enriched at genes with high promoter-proximal Pol
II pausing (C) and is likely to regulate the transition from initiation to productive elongation, in a DSIF and NELF independent manner. Apart from regulating initiation,
cohesin is also responsible for efficient transcription termination between convergent genes throughout the cell cycle (D). Furthermore, cohesin maintains genome
integrity via facilitating homologous recombination repair between sister chromatids (E), upon any DNA damage.