| Ref. |
Organ/Tissue |
Host |
Target genes |
Delivery route |
Dose |
| [62] |
transplanted tumor (H1299) |
BALB/C nude mouse |
Ku80 |
intratumor injection |
day0(1shot) or
day 2, 4(2 shots) |
| [79] |
transplanted tumor (HeLa) |
SCID mouse |
Rad51 |
intratumor injection |
35 μg, Day 0, 2, 4 |
| [85] |
transplanted tumor (B16-F10) |
Mouse |
Rad51 |
intratumor injection |
2.5 nmol, day 6,8,10 |
| [89] |
transplanted tumor (U-118MG) |
Mouse |
Eg5 |
intratumor injection |
200 pmol, day7,10,13 |
| [94] |
transplanted tumor (colon26) |
Mouse |
bcl-2 |
intratumor injection |
40 μg/1shot |
| [97] |
transplanted tumor(A549) |
Mouse |
Nrf2 |
intratumor injection |
day 1,2,3 |
| [80] |
submandibular gland |
Rat |
rCLCA(Ca2+-dependent clchannels), CFTR(cystic fibrosis transmembrane conductance regulator) |
retrograde ductal injection |
2 nmol, day 0 |
| [83] |
submandibular gland |
Rat |
CFTR (cystic fibrosis transmembrane conductance regulator) |
retrograde ductal injection |
2 nmol day 0 |
| [81] |
colon |
Mouse |
IL-13 Receptorα2 |
intrarectal injection |
|
| [82] |
colon |
Mouse |
IRF4 |
intrarectal injection |
100 μg, day-2,1-,0,1 |
| [87] |
colon |
Mouse |
Toll like receptor(TLR)-2 |
intrarectal injection |
1 mg |
| [86] |
spinal cord |
Mouse |
GlyT1, GlyT2, GlyRα3 |
spinal cord injection |
0.45 pmol |
| [88] |
spinal cord |
Mouse |
GlyR α3 |
spinal cord injection |
0.45 pmol |
| [100] |
spinal cord |
Mouse |
Phospholipase C-related but catalytical inactive protein (PRIP) |
spinal cord injection |
0.45 pmol |
| [92] |
brain |
Rat |
Ca(v)3.2 |
intrathecal(i.t) injection |
9 μg/1shot |
| [98] |
brain |
Mouse |
CD45 |
intracerebroventricular (ICV) injection |
5 μg |
| [99] |
brain |
Mouse |
GlyRα3 siRNA |
intrathecal injection |
|
| [96] |
dorsal horn |
Rat |
NK1 receptor |
intrathecal injection |
45 pmol/1shot, day0 |
| [51] |
lung |
Mouse |
IL-13 Receptorα2 |
Intratracheal injection |
100 μg, day0,2,4,6,8,10, 12, 14, 16, 18, 20, 22 |
| [84] |
inguinal and popliteal LN cells
(enrich in lymphoblasts) |
SJL/J mouse (ex vivo ) |
orphan nuclear receptor NR4A2 |
adoptive transfer experimental
autoimmune encephalomyelitis (EAE)
model in irradiated mice/ intraperitoneal injection
of NR4A2 siRNA-treated LN cells |
|
| [90] |
spleen |
Mouse |
Histamine H4 Receptors |
tail vein |
50 μg |
| [91] |
stomach |
Mouse |
Stat1 |
intraperitoneal injection |
100 μg |
| [93] |
uterus |
Mouse |
RCAS1 |
uterine cavity |
|
| [95] |
dorsal skin |
Mouse |
Int6 |
subcutaneous injection |
40 μg |
|
