Stages |
Biochemical Parameters and clinical symptoms |
Stage 0 |
No biochemical and clinical abnormalities |
Stage 1 |
Increased TS (>45%), normal serum ferritin
No clinical symptoms |
Stage 2 |
Increased TS, increased serum ferritin (>200µg/L in females and >300 µg/L in males)
No clinical symptoms |
Stage 3 |
Abnormalbiochemical values
Initial clinicalsymptoms (fatigue, arthritis, impotence, skin hyperpigmentation) |
Stage 4 |
Abnormal biochemical values
Clinical symptoms manifesting organ damage (cirrhosis, diabetes, hypogonadism, or cardiomyopathy) |
Scale proposed by the Haute Autorité de Santé as clinical recommendations on
the HH management [14] |
