Case no./Age (years)/ sex Histopathologic characteristics of tumors hMSH2/ control mRNAa hMLH1/ control mRNAa hMSH6/ control mRNAa hPMS2/ control mRNAa Tumor/ANT MMR mRNA expressionb
Grade Stage LN NF VF TL Tumor ANT Tumor ANT Tumor ANT Tumor ANT hMSH2 hMLH1 hMSH6 hPMS2
1/F/66 WD I 0/16 no no right 1.7 1.73 3.52 4.55 4.81 1.88 0.0478 0.00934 0.982 0.773 2.56 5.12
2/M/80 MD I 0/1 no no rectum 0.0000127 0.0235 0.000139 0.001596 2.27 2.59 0.00339 0.004 0.000539 0.0871 0.878 0.847
3/M/85 MD I 0/5 Y no rectum 3.51 0.911 7.7 1.9 95.1 319 0.722 0.042 3.85 4.05 0.298 17.2
4/F/72 MD I 0/15 no no sigmoid n.i. 0.00033 4.44 0.0255 2.31 3.7 0.0487 0.0718 0.000 174 0.626 0.678
5/M/64 MD I 0/23 no no rectum 0.0276 n.a. 0.97 36.6 2.67 7.23 0.0015 0.743 na 0.0265 0.369 0.00202
6/M/60 MD IIA 0/13 Y no rectum 2.06 0.828 572 177 0.145 1.54 0.0237 0.0263 2.49 3.22 0.0941 0.901
7/M/79 MD IIA 0/1 Y no rectum 0.00345 0.00146 0.000013 0.0000302 1.08 854 0.00232 0.0000459 2.37 0.43 12.7 50.5
8/M/75 MD IIA 0/16 no no sigmoid 0.0787 n.a. 1.42 1.9 0.198 0.785 0.000518 0.000138 n.i. 0.747 0.252 3.75
9/M/75 MD IIA 0/22 no no right 5.8 0.0000721 33.5 3.6 7.19 1.87 0.043 0.169*10-8 80500 9.31 3.83 254*105
10/M/66 MD IIA 0/21 no no right 2.15 1.66 4.12 3.93 184 80.1 0.199 0.116 1.29 1.05 2.3 1.72
11/M/78 MD IIA 0/0 no no sigmoid 44.9 n.a. 762 0.00297 0.0316 n.a. 0.0136 0.000 n.i. 256000 n.i. n.i.
12/M/74 MD IIA 0/17 no no n.a. 0.091 0.0325 0.000053 0.0000133 0.796 1.91 0.000639 0.000788 2.8 3.98 0.417 0.811
13/F/73 MD IIA 0/19 no Y right 0.0901 0.00286 9.58 2.48 1.01 0.616 0.00428 0.000284 315 3.86 1.64 15.1
14/F/64 MD IIA 0/4 Y no rectum 0.373 0.131 0.00018 0.000111 1.55 1.24 0.00126 0.00138 2.86 1.62 1.25 0.909
15/F/74 MD IIA 0/31 Y Y right 0.0294 0.0000112 7.61 4.71 1.05 0.201 0.00186 0.000171 2620 1.62 5.2 10.9
16/F/75 MD IIA 0/26 Y Y right 0.00843 0.0113 15.3 17 2.89 1.31 0.000334 0.00091 0.748 0.9 2.21 0.367
17/F/83 MD IIA 0/8 Y no rectum 0.939 1.28 1.91 4.31 29 3.37 0.0696 0.0155 0.733 0.442 8.62 4.49
18/M/77 M/PD IIA 0/4 Y Y rectum 0.155*10-7 0.0000196 0.0000908 0.000859 0.646 2.76 0.000325 0.0457 0.000788 0.106 0.234 0.00711
19/M/82 PD IIA 0/38 Y Y left 0.0715 0.035 2.52 0.0000194 2.54 13 0.000126 0.000103 2.04 130000 0.195 1.22
20/F/67 MD IIB 0/1 no no rectum 6 0.146 63.7 2.52 0.0367 0.000308 0.00711 0.0000504 41.1 25.3 119 141
21/M/73 MD IIIB 2/14 Y Y right 0.00000788 0.0000187 0.0000242 0.0014 0.284 22 0.000355 0.0408 0.422 0.0173 130 0.0087
22/M/82 MD IIIB 2/32 Y Y right 0.0906 0.216 1.61 2.64 1.96 39.2 0.0482 0.00000169 0.419 0.61 0.0501 286000
23/F/73 MD IIIB 3/22 Y Y right 0.882 0.0577 0.0000293 0.00000928 0.49 1.37 0.000868 0.00172 15.3 3.16 0.357 0.505
24/F/55 MD IIIB 2/9 Y no sigmoid 0.000000285 0.00561 0.16 2.84 0.246 1.06 0.00112 0.00151 0.0000507 0.0563 0.231 0.741
25/F/76 MD IIIB 3/13 y y sigmoid 0.0543 0.00616 0.952 3.04 0.000114 0.00256 0.000121 0.0000114 8.83 0.313 0.044 0.0000114
26/M/67 PD IIIB 1/14 no no sigmoid 2.24 1.95 5.17 3.63 200 31.2 0.0118 0.0943 1.15 1.42 6.41 0.126
27/F/52 MD IIIC 27/45 y y rectum 0.00510 0.00824 0.000000988 0.00000273 1.05 1.84 0.000259 0.000448 0.619 0.362 0.573 0.578
28/F/63 MD IIIC 10/22 no no right 0.834 1.96 879 1560 19.4 49.8 0.0882 0.0649 0.424 0.564 0.39 1.36
29/M/92 M/PD IIIC 7/13 y y rectum 0.446 0.504 0.937 3.45 0.0762 1.27 0.0301 0.0195 0.885 1.41 0.0598 1.54
30/M/67 PD IIIC 7/8 y y n.a. 0.393 0.563 0.963 1.33 5.84 55.1 0.0252 0.0888 0.697 0.725 0.106 0.284
31/F/80 M/PD IIIC 1/38 y y n.a. 0.00028 0.000711 4.05 2.42 3.29 0.487 0.000341 0.000301 0.393 1.67 6.74 1.13
ANT, adjacent normal tissue; WD, well differentiated tumors; MD, moderately differentiated tumors; M/PD, moderately-poorly differentiated tumors; PD, poorly differentiated tumors; LN, lymph node metastasis; NF, nerve infiltration; VF, vessel infiltration; TL, tumor localization; n.a. not availiable; aRatios of mRNA expression; bRatios of tumor to ANT mRNA expression.
Table 1: Quantitative mRNA expression of MMR DNA repair genes in colorectal adenocaricnomas and their adjacent normal tissues.