Control High-risk T1DM*         n MAF (%) n MAF (%) OR 95%CI P value 1st panel 263 (5.1) 124 (1.2) 0.23 0.08-0.71 0.001 2nd panel 346 (5.1) 507 (3.0) 0.57 0.35-0.94 0.026 Summary 609 (5.1) 631 (2.6) 0.47 0.30-0.74 0.00097 P value for heterogeneity: p= 0.15 *High-risk type 1 diabetes: INS-VNTR classes I / I at IDDM2 locus, MAF: minor allele frequency, OR: Odds ratio

Table 5: Meta-analysis of association studies of MAFA Gly346Cys with susceptibility to high-risk type 1 diabetes in Japanese population.