| Aceview mapping of homologues of the DAF-12/VDRtarget genes to key genes described in recent AD or associated cancer-related publications |
| Gene (Human homologue of the VDR target/C.eleganshomologue of the DAF-12 target) |
Type of diseases |
References |
| ZGPAT/C33H5.17 |
UC,CD |
[21] |
| CCR7 /R106.2 |
T1D |
[21] |
| PLCL/pll-1 |
CD,DM |
[13,21] |
| RPL19PB/rpl19 |
MS |
[21] |
| TNFAIP3/Y59C1A.1 |
RA, SLE, UC, SSc |
[21] |
| Pxk/ wnk-1 |
SLE |
[21] |
| IKZF1/PRDM16/egl-43,the closest DAF-12/VDR binding loci 15 kb distant from the R53.5, R53.6, R53.7a, R53.8 regions. |
CD |
[21] |
| BLK/src-1 |
SLE,RA,DM |
[13, 21] |
| RBPj/lag-1 |
T1D, RA |
[21] |
| GOT1/T01C8.5 |
CD, UC |
[21] |
| Jak2/csnk-1/Y106G6E.6 |
CD, UC |
[21] |
| IFIH1/drh-1 |
Multiple |
[21] |
| Jak2/ csnk-1 |
CD, UC |
[23] |
| NKX2.3/ceh-24. |
CD,UC |
[23] |
| SMAD3/daf-3. |
|
[23] |
| PRDM1/blmp-1, the closest DAF-12/VDR binding locus in ChIP-chip online target list <10 kb distant from the Y106G6H.1 region. |
CD,UC |
[23] |
| HNF4a/nhr-64. |
UC |
[23] |
| LAMB1/lam-1/W03F8.5. |
UC |
[23] |
| xpa-1 /K07G5.2, the closest DAF-12/VDR binding locus in the ChIP-chip online target list to the K07G5.1 and K07G5.6 regions. |
PND |
[17] |
| Smarcal1/C16A3.1, the closest DAF-12/VDR binding locus in the ChIP-chip online target list to the C16A3.6, C16A3.7a, C16A3.8and C16A3.11 regions. |
PND |
[17] |
| ELF1/elf-1. |
PND |
[17] |
| DBR1/C55B7.8 the closest DAF-12/VDR binding locus in the ChIP-chip online target list 5 kb distant from the C55B7.3 region. |
PND |
[17] |
| TIFα/TRIM24/flt-1 |
DM, cancer |
[18,27] |
| TIFβ/TRIM28/ncl-1 |
DM, cancer |
[18] |
| TIFγ/TRIM33/nhl-2 |
DM, cancer |
[18] |
| AIRE/Mi-2β/let-418 |
DM, cancer |
[22,24] |
| Foxp3/fkh-7 |
DM, cancer |
[22,24] |
| ADAM33/adm-2 |
Asthma |
[22] |
| GPRA/gnrr-1/F5D7.3 |
Asthma |
[22] |
| RPC-1/rpc-1 |
SSC, cancer |
[14] |
| Topoisomerase I /top1 |
SSC |
[14] |
Note 1: T1D: Type 1 Diabetes; SLE: Systemic lupus erythematosus; DM: dermatomyositis; SSc: Systemic scleroderma; CD: Crohn's disease; CeLD: Celiac disease;
MS: multiple sclerosis; RA: Rheumatoid arthritis; PND: Paraneoplastic neurological disorder; UC: Ulcerative colitis.
Note 2: the original full list for the DAF-12/VDR target genes online target is available in the supplementary materials [8]. See NCBI Aceview for their human
homologues or vice versa. |
