Cough-variant asthma Atopic cough Eosinophilic bronchitis without asthma
Pathologic findings Eosinophilic inflammation Central to peripheral airways Central airway Central airway peripheral airway
Physiologic findings Slightly increased tonus of bronchial smooth muscle and bronchoconstriction due to mild airway hyperresponsiveness Normal airway responsiveness Increased cough receptor sensitivity Normal airway responsiveness Increased cough receptor sensitivity
Mechanism of cough Mediated by bronchoconstriction Due to increased cough receptor sensitivity Probably due to increased cough receptor sensitivity
Presence of cough required for diagnosis Yes Yes No
Table 6: Summary of pathophysiological findings in cough-variant asthma, atopic cough and non-asthmatic eosinophilic bronchitis