Gene Exon/Intron Systematic Nomenclature Amino Acid modification References BRCA1 exon 2 c.68_69delAG Stop39 Laarabi et al. [5]   exon 5 c.181T>G C61G Tazzite et al. [5]   exon 11 c.798_799delTT Stop285 Tazzite et al. [4]   exon 11 c.2805delA Stop999 Laraqui et al. [6]   exon 11 c.3279delC Stop1108 Tazzite et al. [4]   exon 11 c.1016dupA Stop345 Laraqui et al. [6]   exon 16 c.4942A>T Stop1648 Laraqui et al. [6]   exon 11b c.1186A>G Q356R Tazzite et al. [7]   exon 11b c. 1100A>G T327T Tazzite et al. [7]   exon 17 c.5062-5064delGTT V1688del Tazzite et al. [4]   exon 18 c.5095C>T R1699W Laraqui et al. [6] BRCA2 exon 11 c.3381delT Stop1150 Tazzite et al. [4]   exon 11 c.5073dupA W1692MfsX3 Laarabi et al. [5]   exon 14 c.7110delA Stop2376 Tazzite et al. [4]   exon 14 c.7235insG Stop2413 Tazzite et al. [4]   intron 6 c.517-1G>A   Tazzite et al. [4]

Table 2: BRCA1 and BRCA2 pathogenic germline mutations found in Moroccan population