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Figure 5: SFOLD analysis of the intronic region containing the pseudo-exon. The 72 bp pseudo-exon and 60 bp of intronic sequence on either side were used for analysis. The accessibility profile for normal transcripts is shown in (a), aligned with ESE sites predicted using ESE finder (http://rulai.cshl.edu/cgi-bin/tools/ESE3/esefinder.cgi?process=home). (b)- (g) show the predicted accessibility profile if AOs are bound to the transcript. The asterix indicates a region of interest. |