Drug Name Target HBV Peg-Interferon a-2A Interferon a-2B Entecavir adefovirdipivoxil Activates CD8+ T Up-regulates the expression of MHC I proteins Block viral replication Block viral reverse transcription HCV Telaprevir Interferon alfacon-1 Interferon  a-2A Boceprevir Sirneprevir Sofosbuvir HCV NS3-4A inhibitor Increases MHC I expression Activates CD8+ T cells HCV protease inhibitor NS3/4A protease inhibitor HCV NSSB polymerase inhibitor

Table 2: FDA approved drugs and their targets in the treatment of HBV/HCV infection. (Source: Food and Drug Administration).